Photo de stock - Cholinergic neurotransmission. At the level of the cholinergic synapse, the nerve impulse is transmitted between the two neurons thanks to acetylcholine ACh, brown and blue ball. Acetylcholine is synthetized inside the cytoplasm of the presynaptic neuron from choline Ch, blue half_sphere and acetyl group A, brown half_sphere provided by acetyl_coenzyme A Acetyl_S_CoA, in yellow. Acetylcholine, stocked inside synaptic vesicles, is released in the synaptic cleft and fixes to receptors of the postsynaptic neuron nicotinic and muscarinic receptors, in blue. It is then degraded by the acetylcholinesterase AChE into choline and acetate. The choline is then recapted by the presynaptic neuron and reused. The rate of acetylcholine being reduced in the brain of individuals affected with Alzheimer´s disease, acetylcholinesterase inhibitors galantamine, donepezil are used in the framework of the treatment of the disease.